N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

Base Information

Chemical Name:N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide
CAS No.:1491169-44-8
Molecular Formula:C₂₅H₁₅F₇N₂O₃S₂
Molecular Weight:588.527
Hs Code.:

Synonyms:N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

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Chemical Property of N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

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Technology Process of N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

There total 7 articles about N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 41507-35-1
3-thiophene carboxylic acid chloride

: 1491169-37-9
N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

: 1491169-44-8
N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

Guidance literature:: N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

3-thiophene carboxylic acid chloride; With potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 1491168-99-0
ethyl 4-(2-fluorophenyl)nicotinate

: 1491169-44-8
N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

3.1: triphenylphosphine / water; tetrahydrofuran / 20 °C

4.1: hydrogenchloride

5.1: triethylamine / dichloromethane / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1491169-44-8
N-(3,5-bis(trifluoromethyl)phenylsulfonyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 12 h / 85 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

4.1: triphenylphosphine / water; tetrahydrofuran / 20 °C

5.1: hydrogenchloride

6.1: triethylamine / dichloromethane / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

7.2: 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: |Suzuki Coupling / 4.1: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050