N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Base Information

Chemical Name:N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea
CAS No.:852660-72-1
Molecular Formula:C₂₉H₃₉FN₆O₂
Molecular Weight:522.666
Hs Code.:

Synonyms:N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

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Chemical Property of N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

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Technology Process of N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

There total 23 articles about N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852660-74-3
N-(1-methyl-indazol-5-yl)-phenylcarbamate

: 852660-67-4
C₂₀H₃₂FN₃O

: 852660-72-1
N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

: 852660-73-2
N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-72-1
N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

: 852660-73-2
N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: borane-THF / tetrahydrofuran / 25 °C / Heating / reflux

3.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

4.1: tetrahydrofuran / 25 °C

5.1: dichloromethane / 0.5 h / 20 °C

5.2: 16 h / 20 °C

6.1: hydrogenchloride / water; acetonitrile / 24 h / 20 °C

7.1: ethanol / 0.5 h

7.2: 72 h / 20 °C

8.1: triethylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr

10.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; borane-THF; water; hydrogen; phosphorus tribromide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852660-72-1
N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5R)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

: 852660-73-2
N-(1-methyl-indazol-5-yl)-N'-[(1R,2S,5S)-5-(N-methyl)acetamido-2-[N-methyl-3-(4-fluorophenyl)propylamino]methyl-cyclohexyl]urea

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.2: 1 h

3.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

4.1: tetrahydrofuran / 25 °C

5.1: dichloromethane / 0.5 h / 20 °C

5.2: 16 h / 20 °C

6.1: hydrogenchloride / water; acetonitrile / 24 h / 20 °C

7.1: ethanol / 0.5 h

7.2: 72 h / 20 °C

8.1: triethylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr

10.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;