(4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

Base Information

Chemical Name:(4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone
CAS No.:73062-20-1
Molecular Formula:C₁₅H₁₇NO₄
Molecular Weight:275.304
Hs Code.:

Synonyms:(4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

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Chemical Property of (4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

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Technology Process of (4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

There total 9 articles about (4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.5%

: 73062-08-5
Methanesulfonic acid (4S,5R)-4-methoxy-3-methyl-2-oxo-4-[(E)-(3-phenyl-acryloyl)]-oxazolidin-5-ylmethyl ester

: 73062-20-1
(4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; 1.) 0 deg C, 3 h, 2.) 25 deg C, 2 h;
DOI:10.1021/jo01296a021

Reference yield:

: 73061-98-0
2-Hydroxyethyl N-(1-Methoxy-2-oxo-4-phenyl-3(E)-butenyl)-N-methylcarbamate

: 73062-20-1
(4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent Turnov_. / Pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 0.17 h / Heating

2: 55 percent / K₂CO₃ / methanol / 18 h / 25 °C

3: pyridine / 25 °C

4: LiEt₃BH

With sodium acetate; lithium triethylborohydride; potassium carbonate; pyridinium chlorochromate; In pyridine; methanol; dichloromethane;
DOI:10.1021/jo01296a021

Reference yield:

: 73062-01-8
2-Oxoethyl (1-methoxy-2-oxo-4-phenyl-3(E)-butenyl)-N-methylcarbamate

: 73062-20-1
(4RS,5RS)-1-Methyl-3-oxa-5-(1',4-epoxymethylenocinnamyl)-5-methoxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / K₂CO₃ / methanol / 18 h / 25 °C

2: pyridine / 25 °C

3: LiEt₃BH

With lithium triethylborohydride; potassium carbonate; In pyridine; methanol;
DOI:10.1021/jo01296a021