ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

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Chemical Name:ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate
CAS No.:1173983-00-0
Molecular Formula:C₂₂H₂₆Cl₂N₄O₂
Molecular Weight:449.38
Hs Code.:

Synonyms:ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

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Chemical Property of ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

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Technology Process of ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

There total 5 articles about ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1173982-99-4
ethyl 3-{7-amino-2-[(2,4-dichlorophenyl)amino]-1H-benzimidazol-1-yl}propanoate

: 75-07-0,9002-91-9
acetaldehyde

: 1173983-00-0
ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

Guidance literature:: ethyl 3-{7-amino-2-[(2,4-dichlorophenyl)amino]-1H-benzimidazol-1-yl}propanoate; acetaldehyde; With acetic acid; In methanol; at 0 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In methanol; at 0 - 20 ℃;

Reference yield:

: 1173982-97-2
ethyl N-(2,6-diaminophenyl)-β-alaninate

: 1173983-00-0
ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / 50 °C

3.1: acetic acid / methanol / 0.5 h / 0 °C

3.2: 12 h / 0 - 20 °C

With acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2018.01.020

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 1173983-00-0
ethyl 3-[2-[(2,4-dichlorophenyl)amino]-7-(diethylamino)-1H-benzimidazol-1-yl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 6 h / 20 °C

3.1: tetrahydrofuran / 1 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / 50 °C

5.1: acetic acid / methanol / 0.5 h / 0 °C

5.2: 12 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2018.01.020