3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

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Chemical Name:3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide
CAS No.:175355-11-0
Molecular Formula:C₄₈H₅₁N₅O₈
Molecular Weight:825.962
Hs Code.:

3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

Synonyms:3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

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Chemical Property of 3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

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Technology Process of 3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

There total 3 articles about 3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 175355-10-9
3-[1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

: 175355-11-0
3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

Guidance literature:: In pyridine; for 6h; Ambient temperature;
DOI:10.1021/jo9518213

Reference yield:

: 128870-20-2
5-(2-carbethoxyethyl)-2'-deoxyuridine

: 175355-11-0
3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / EDC / dimethylformamide / 30 h / Ambient temperature

2: 48 percent / pyridine / 6 h / Ambient temperature

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo9518213

Reference yield:

: 115021-71-1
4-(4-aminobutyl)-4'-methyl-2,2'-bipyriridine

: 175355-11-0
3-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-[4-(4'-methyl-[2,2']bipyridinyl-4-yl)-butyl]-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / EDC / dimethylformamide / 30 h / Ambient temperature

2: 48 percent / pyridine / 6 h / Ambient temperature

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo9518213