Technology Process of (2R,3R,5S,6S)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-6-(4-methoxybenzyloxy)-2,5-dimethylheptanoate
There total 5 articles about (2R,3R,5S,6S)-((1R,2S)-2-(N-benzyl-2,4,6-trimethylphenylsulfonamido)-1-phenylpropyl) 3-hydroxy-6-(4-methoxybenzyloxy)-2,5-dimethylheptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(1R,2S)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate;
With
triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane;
In
hexane; dichloromethane;
at -78 ℃;
for 3h;
(3S,4S)-4-(4-methoxybenzyloxy)-3-methylpentanal;
In
hexane; dichloromethane;
at -78 - 23 ℃;
for 3h;
With
water; dihydrogen peroxide;
In
methanol;
DOI:10.1021/ol902110a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / 0 - 23 °C
3.1: ozone / dichloromethane / -78 °C
3.2: -78 - 20 °C
4.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / dichloromethane / 3 h / -78 °C
4.2: 3 h / -78 - 20 °C
4.3: 20 °C
With
dmap; lithium aluminium tetrahydride; ozone; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane;
In
tetrahydrofuran; diethyl ether; dichloromethane;
4.1: Aldol reaction / 4.2: Aldol reaction;
DOI:10.1016/j.tet.2011.07.066
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / 0 - 23 °C
2.1: ozone / dichloromethane / -78 °C
2.2: -78 - 20 °C
3.1: triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane / dichloromethane / 3 h / -78 °C
3.2: 3 h / -78 - 20 °C
3.3: 20 °C
With
lithium aluminium tetrahydride; ozone; triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane;
In
tetrahydrofuran; diethyl ether; dichloromethane;
3.1: Aldol reaction / 3.2: Aldol reaction;
DOI:10.1016/j.tet.2011.07.066
