3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Base Information

Chemical Name:3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile
CAS No.:850607-53-3
Molecular Formula:C₂₃H₂₆N₂
Molecular Weight:330.473
Hs Code.:

Synonyms:3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

There total 8 articles about 3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 850607-72-6
(3-endo)-3-iodomethyl-8-methyl-8-azabicyclo[3.2.1]octane

: 86-29-3
Diphenylacetonitrile

: 850607-53-3
3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm900736e

Reference yield:

: 1131911-30-2
3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile trifluoroacetate

: 850607-53-3
3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Guidance literature:: With potassium carbonate; In acetonitrile; for 0.333333h; Purification / work up;

Reference yield:

: 852460-98-1
[(3-endo)-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]methanol

: 850607-53-3
3-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-2,2-diphenylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; hydrogen / palladium hydroxide on carbon / ethanol; water / 66 h / 20 °C / 2844.39 Torr

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 80 °C / Microwave

3.1: iodine; triphenylphosphine / dichloromethane / 17 h

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; iodine; sodium hydride; triphenylphosphine; palladium hydroxide on carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;