7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Base Information

• Chemical Name: 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• CAS No.: 1278418-29-3
• Molecular Formula: C₂₂H₁₇F₃N₆O₃
• Molecular Weight: 470.411

Synonyms:7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Chemical Property of 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

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Technology Process of 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

There total 5 articles about 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4,5,6,7-tetrahydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-3-amine hydrochloride (1278418-27-1) → 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (1278418-29-3)

Guidance literature:

4,5,6,7-tetrahydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-3-amine hydrochloride; 7-halo-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid diacetoxyborane chelate complex; With triethylamine; In acetonitrile; at 25 - 60 ℃; Inert atmosphere;

With water; sodium hydroxide; at 40 ℃;

DOI:10.3390/molecules16032626

Reference yield:

ethyl 3-((tert-butoxycarbonyl)(2-cyanoethyl)amino)propanoate (266353-22-4) → 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (1278418-29-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / toluene; mineral oil / 1.5 h / 110 °C

2.1: ethanol / 12 h / 20 °C

3.1: hydrogenchloride / methanol / 1 h / 20 °C

4.1: triethylamine / acetonitrile / 25 - 60 °C / Inert atmosphere

4.2: 40 °C

With hydrogenchloride; sodium hydride; triethylamine; In methanol; ethanol; toluene; acetonitrile; mineral oil;

DOI:10.3390/molecules16032626

Reference yield:

(±)-tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate (914988-10-6) → 7-(3-amino-6,7-dihydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (1278418-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 12 h / 20 °C

2.1: hydrogenchloride / methanol / 1 h / 20 °C

3.1: triethylamine / acetonitrile / 25 - 60 °C / Inert atmosphere

3.2: 40 °C

With hydrogenchloride; triethylamine; In methanol; ethanol; acetonitrile;

DOI:10.3390/molecules16032626

upstream raw materials:

ethyl 3-((tert-butoxycarbonyl)(2-cyanoethyl)amino)propanoate

(±)-tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate

tert-butyl (3-amino-4,5,6,7-tetrahydro-2-methyl-2H-pyrazolo[4,3-c]pyridine)-5-carboxylate

4,5,6,7-tetrahydro-2-methyl-2H-pyrazolo[4,3-c]pyridin-3-amine hydrochloride

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