(5''-CHLORO-2'',3''-DIMETHOXY)ACETOPHENONE

Base Information

• Chemical Name: (5''-CHLORO-2'',3''-DIMETHOXY)ACETOPHENONE
• CAS No.: 117052-19-4
• Molecular Formula: C10H11 Cl O3
• Molecular Weight: 214.649
• Hs Code.: 2914700090
• Mol file: 117052-19-4.mol

Synonyms:(5’’-CHLORO-2’’,3’’-DIMETHOXY)ACETOPHENONE

Chemical Property of (5''-CHLORO-2'',3''-DIMETHOXY)ACETOPHENONE

Chemical Property:

• Boiling Point: 300.4°Cat760mmHg
• Flash Point: 124.6°C
• PSA: 35.53000
• Density: 1.186g/cm³
• LogP: 2.55980

Purity/Quality:

98%min ^*data from raw suppliers

(5''-Chloro-2'',3''-dimethoxy)acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5''-CHLORO-2'',3''-DIMETHOXY)ACETOPHENONE

There total 2 articles about (5''-CHLORO-2'',3''-DIMETHOXY)ACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(5-chloro-2,3-dimethoxy-phenyl)-ethanol (117052-18-3) → 1-(5-chloro-2,3-dimethoxy-phenyl)-ethanone (117052-19-4)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 8h; Reflux;

Reference yield:

5-chloro-2,3-dimethoxybenzaldehyde (86232-28-2) → 1-(5-chloro-2,3-dimethoxy-phenyl)-ethanone (117052-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 2.) ether, benzene, reflux, 6 h

2: 85 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h

With pyridine; chromium(VI) oxide; magnesium; In dichloromethane;

DOI:10.1007/BF00763527

Reference yield: 91.7%

1-(5-chloro-2,3-dimethoxy-phenyl)-ethanone (117052-19-4) → 1-(5-chloro-2,3-dimethoxy-phenyl)-ethylamine (903581-03-3)

Guidance literature:

1-(5-chloro-2,3-dimethoxy-phenyl)-ethanone; With titanium(IV) isopropylate; ammonia; In ethanol; at 16 - 32.4 ℃; for 16.08 - 16.16h;

With sodium tetrahydroborate; In ethanol; at 1.4 - 19 ℃; for 4.16h;

With ammonia; In ethanol; water; at 21 - 26 ℃; Product distribution / selectivity;

upstream raw materials:

1-(5-chloro-2,3-dimethoxy-phenyl)-ethanol

5-chloro-2,3-dimethoxybenzaldehyde

Downstream raw materials:

1-(5-Chloro-2,3-dimethoxy-phenyl)-3-dimethylamino-propan-1-one; hydrochloride

1-(5-chloro-2,3-dimethoxy-phenyl)-ethylamine

Refernces

• 1、 -. "SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS". Page/Page column 133-134. . Retrieved 2008/06/13.