(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

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Chemical Name:(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol
CAS No.:1204220-91-6
Molecular Formula:C₅₀H₅₁ClO₆
Molecular Weight:785.388
Hs Code.:

Synonyms:(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

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Chemical Property of (5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

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Technology Process of (5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

There total 7 articles about (5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204220-89-2
methyl 5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)benzoate

: 1204220-91-6
(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

Guidance literature:: methyl 5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)benzoate; With lithium aluminium deuteride; In tetrahydrofuran; at 0 ℃; for 1.5h;

With water; In tetrahydrofuran; for 0.5h;

Reference yield:

: 1204220-79-0
(2S,3R,4R,5S,6R)-2-methoxy-2-(4-chloro-3-(4-cyclopropylbenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

: 1204220-91-6
(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃SiD; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -30 - -20 °C

2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

3.1: sodium perchlorate; dihydrogen peroxide / water; tert-butyl alcohol / 20 °C

4.1: thionyl chloride / 0 °C / Reflux

5.1: lithium aluminium deuteride / tetrahydrofuran / 1.5 h / 0 °C

5.2: 0.5 h

With thionyl chloride; lithium aluminium deuteride; Et₃SiD; boron trifluoride diethyl etherate; sodium perchlorate; dihydrogen peroxide; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1204220-77-8
4-bromo-1-chloro-2-(4-cyclopropylbenzyl)benzene

: 1204220-91-6
(5-chloro-4-(4-ethylbenzyl)-2-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methan-d2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.67 h / -78 - -70 °C / Inert atmosphere

1.2: -65 °C

2.1: Et₃SiD; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / -30 - -20 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

4.1: sodium perchlorate; dihydrogen peroxide / water; tert-butyl alcohol / 20 °C

5.1: thionyl chloride / 0 °C / Reflux

6.1: lithium aluminium deuteride / tetrahydrofuran / 1.5 h / 0 °C

6.2: 0.5 h

With n-butyllithium; thionyl chloride; lithium aluminium deuteride; Et₃SiD; boron trifluoride diethyl etherate; sodium perchlorate; dihydrogen peroxide; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol;