2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide

Base Information

• Chemical Name: 2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide
• CAS No.: 245756-11-0
• Molecular Formula: C₃₈H₆₁ClN₄O₅
• Molecular Weight: 689.379

Synonyms:2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide

Chemical Property of 2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide

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Technology Process of 2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide

There total 15 articles about 2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (122621-77-6) + 4-chloro-2-[(cyclohexylmethyl-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-carbamoyl)-methyl]-pent-4-enoic acid → 2-(2-chloro-allyl)-N4-cyclohexylmethyl-N1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide (245756-11-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo990321x

Reference yield: 56.0%

2-(2-chloro-allyl)-N4-cyclohexylmethyl-N1-(1-cyclohexylmethyl-5-methyl-hex-2-enyl)-N4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide (245756-15-4) → 2-(2-chloro-allyl)-N4-cyclohexylmethyl-N1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide (245756-11-0)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; tert-butyl alcohol; at 5 ℃; for 48h;

DOI:10.1021/jo990321x

Reference yield:

2-<(cyclohexylmethyl)amino>-N-methyl-N-<2-(2-pyridinyl)ethyl>acetamide (192516-54-4) + (S)-5-Chloro-3-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-hex-5-enoic acid (245756-17-6) → 2-(2-chloro-allyl)-N4-cyclohexylmethyl-N1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide (245756-11-0)

Guidance literature:

(S)-5-Chloro-3-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-hex-5-enoic acid; With 4-methyl-morpholine; pivaloyl chloride; In tetrahydrofuran; at 0 - 5 ℃; for 2h;

2-<(cyclohexylmethyl)amino>-N-methyl-N-<2-(2-pyridinyl)ethyl>acetamide; With 4-methyl-morpholine; In tetrahydrofuran; at 5 - 20 ℃;

DOI:10.1021/jo990321x

upstream raw materials:

(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

2-(2-chloro-allyl)-N⁴-cyclohexylmethyl-N¹-(1-cyclohexylmethyl-5-methyl-hex-2-enyl)-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide

2-<(cyclohexylmethyl)amino>-N-methyl-N-<2-(2-pyridinyl)ethyl>acetamide

(S)-5-Chloro-3-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-hex-5-enoic acid

Downstream raw materials:

2-(2-chloro-allyl)-N¹-[2-cyclohexyl-1-(5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-N⁴-cyclohexylmethyl-N⁴-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-succinamide

BILA 2157 BS

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