2-(4-phenyl-but-1-en-3-ynyl)-pyridine

Base Information

Chemical Name:2-(4-phenyl-but-1-en-3-ynyl)-pyridine
CAS No.:92497-49-9
Molecular Formula:C₁₅H₁₁N
Molecular Weight:205.259
Hs Code.:

Synonyms:2-(4-phenyl-but-1-en-3-ynyl)-pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-phenyl-but-1-en-3-ynyl)-pyridine

Chemical Property:

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Technology Process of 2-(4-phenyl-but-1-en-3-ynyl)-pyridine

There total 2 articles about 2-(4-phenyl-but-1-en-3-ynyl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 2579-22-8
Phenylpropargyl aldehyde

: 17881-80-0
(2-picolyl)trimethylsilane

: 92497-49-9
2-(4-phenyl-but-1-en-3-ynyl)-pyridine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)93807-9

Reference yield:

: 2579-22-8
Phenylpropargyl aldehyde

: 38700-15-1
triphenyl-(2-pyridylmethyl)phosphonium chloride

: 92497-49-9
2-(4-phenyl-but-1-en-3-ynyl)-pyridine

Guidance literature:: triphenyl-(2-pyridylmethyl)phosphonium chloride; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

Phenylpropargyl aldehyde; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.202007352

Reference yield:

: 92497-49-9
2-(4-phenyl-but-1-en-3-ynyl)-pyridine

: benzyl (S,E)-2-(4-phenylbut-1-en-3-yn-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: C₄₅H₂₂B₂F₂₀; N-(3,5-bis(trifluoromethyl)phenyl)acetamide; benzyltri(n-butyl)ammonium chloride; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / 24 h / 25 °C / Glovebox; Sealed tube; Inert atmosphere

2: sodium hydroxide / water; diethyl ether / 0 - 20 °C

With N-(3,5-bis(trifluoromethyl)phenyl)acetamide; C₄₅H₂₂B₂F₂₀; benzyltri(n-butyl)ammonium chloride; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; sodium hydroxide; In diethyl ether; water;
DOI:10.1002/anie.202007352