1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine

Base Information

• Chemical Name: 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine
• CAS No.: 132885-39-3
• Molecular Formula: C₂₀H₃₁N₃O₃SSi
• Molecular Weight: 421.636

Synonyms:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine

Chemical Property of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine

Chemical Property:

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Technology Process of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine

There total 2 articles about 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-4-(3-nitro-1,2,4-triazol-1-yl)-5-methyl-6-(phenylthio)pyrimidin-2-one (132885-38-2) → 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine (132885-39-3)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; for 6h; Yield given; Ambient temperature;

DOI:10.1021/jm00108a023

Reference yield:

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)thymine (123027-51-0) → 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine (132885-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphate, pyridine / 168 h / Ambient temperature

2: aq. ammonia / dioxane / 6 h / Ambient temperature

With pyridine; ammonium hydroxide; diphenyl hydrogen phosphate; In 1,4-dioxane;

DOI:10.1021/jm00108a023

Reference yield: 79.0%

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-methyl-6-(phenylthio)cytosine (132885-39-3) → 1-[(2-hydroxyethoxy)methyl]-5-methyl-6-phenylthiocytosine (125057-05-8)

Guidance literature:

With acetic acid; In tetrahydrofuran; for 14h; Ambient temperature;

DOI:10.1021/jm00108a023

upstream raw materials:

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-4-(3-nitro-1,2,4-triazol-1-yl)-5-methyl-6-(phenylthio)pyrimidin-2-one

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)thymine

Downstream raw materials:

1-[(2-hydroxyethoxy)methyl]-5-methyl-6-phenylthiocytosine

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