2-(p-Tolyl)-4'-methyl-acrylophenon

Base Information

• Chemical Name: 2-(p-Tolyl)-4'-methyl-acrylophenon
• CAS No.: 28322-76-1
• Molecular Formula: C₁₇H₁₆O
• Molecular Weight: 236.313
• Mol file: 28322-76-1.mol

Synonyms:2-(p-Tolyl)-4'-methyl-acrylophenon

Chemical Property of 2-(p-Tolyl)-4'-methyl-acrylophenon

Chemical Property:

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Technology Process of 2-(p-Tolyl)-4'-methyl-acrylophenon

There total 1 articles about 2-(p-Tolyl)-4'-methyl-acrylophenon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 4-methyl-benzaldehyde (104-87-0) → 2-(p-Tolyl)-4'-methyl-acrylophenon (28322-76-1)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 3-(2,6-diisopropylphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate; 3,5,3',5'-tetra-tert-butyl-4,4'-diphenoquinone; sodium benzenesulfonate; potassium carbonate; In dimethyl sulfoxide; at 20 ℃; Irradiation;

DOI:10.1021/acscatal.1c02890

Reference yield: 93.0%

3,5-dimethyl-4-nitro-1H-pyrazole (14531-55-6) + 2-(p-Tolyl)-4'-methyl-acrylophenon (28322-76-1) → (S)-3-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)-1,2-di-p-tolylpropan-1-one

Guidance literature:

With hydrogenchloride; C₃₉H₆₀N₄O₄; scandium (III) chloride hexahydrate; In chloroform; at 30 ℃; for 17h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201400616

Reference yield: 44.0%

methyl 2-diazohydrocinnamate (51507-18-7) + 2-(p-Tolyl)-4'-methyl-acrylophenon (28322-76-1) → C27H26O3 + C27H26O3

Guidance literature:

With C₃₈H₅₈N₄O₄; scandium tris(trifluoromethanesulfonate); In dichloromethane; at 0 ℃; for 72h; enantioselective reaction;

DOI:10.1039/c8cc05420g

upstream raw materials:

1-ethenyl-4-methylbenzene

4-methyl-benzaldehyde