6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one

Base Information

• Chemical Name: 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one
• CAS No.: 156706-75-1
• Molecular Formula: C₄₂H₅₄N₆O₆Si
• Molecular Weight: 767.013
• Mol file: 156706-75-1.mol

Synonyms:6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one

Chemical Property of 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one

There total 4 articles about 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

triisopropylsilyl chloride (13154-24-0) + 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-<5'-O-(4-methoxytriphenylmethyl)-β-D-ribofuranosyl>-2H-purin-2-one (156706-73-9) → 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one (156706-75-1) + 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-2'-O--β-D-ribofuranosyl)-2H-purin-2-one (156706-74-0)

Guidance literature:

With silver nitrate; In tetrahydrofuran; pyridine; for 48h; Ambient temperature;

DOI:10.1002/hlca.19940770137

Reference yield: 12.0%

6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-2'-O--β-D-ribofuranosyl)-2H-purin-2-one (156706-74-0) → 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one (156706-75-1)

Guidance literature:

In pyridine; for 70h; isomerization in various solvents;

DOI:10.1002/hlca.19940770137

Reference yield:

1,2-dihydro-2-oxoadenosine (1818-71-9) → 6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-3'-O--β-D-ribofuranosyl)-2H-purin-2-one (156706-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / dimethylformamide / 12 h / Ambient temperature

2: 73.4 percent / (i-Pr)2EtN / pyridine / 12 h / 60 °C

3: 6 percent / AgNO₃ / pyridine; tetrahydrofuran / 48 h / Ambient temperature

With silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19940770137

upstream raw materials:

triisopropylsilyl chloride

6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-<5'-O-(4-methoxytriphenylmethyl)-β-D-ribofuranosyl>-2H-purin-2-one

6-(<(dimethylamino)methylidene>amino)-1,9-dihydro-9-(5'-O-(4-methoxytriphenylmethyl)-2'-O--β-D-ribofuranosyl)-2H-purin-2-one

1,2-dihydro-2-oxoadenosine