N¹-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine

Base Information

• Chemical Name: N¹-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine
• CAS No.: 911432-18-3
• Molecular Formula: C₄₅H₅₉N₅O₆Si
• Molecular Weight: 794.079

Synonyms:N¹-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine

Chemical Property of N¹-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine

Chemical Property:

Purity/Quality:

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Technology Process of N¹-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine

There total 3 articles about N¹-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N1-[(6''-hydroxy)hexyl]-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine (911432-14-9) + mono-4-methoxytrityl chloride (14470-28-1) → N1-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine (911432-18-3)

Guidance literature:

With pyridine; at 20 ℃; for 8h;

DOI:10.1021/jm060320e

Reference yield:

6-amino-1-hexanol (4048-33-3) → N1-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine (911432-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / methanol / 4 h / 20 °C

2: 89 percent / pyridine / 8 h / 20 °C

With pyridine; potassium carbonate; In methanol;

DOI:10.1021/jm060320e

Reference yield:

5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile (368870-20-6) → N1-(monomethoxytrityloxyhexyl)-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine (911432-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / K₂CO₃ / methanol / 4 h / 20 °C

2: 89 percent / pyridine / 8 h / 20 °C

With pyridine; potassium carbonate; In methanol;

DOI:10.1021/jm060320e

upstream raw materials:

N¹-[(6''-hydroxy)hexyl]-5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylideneadenosine

mono-4-methoxytrityl chloride

6-amino-1-hexanol

5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile

Downstream raw materials:

N¹-(6''-monomethoxytrityloxyhexyl)-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

N¹-(6''-phosphonoxyhexyl)-5'-O-[(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

N¹-[(6''-hydroxy)hexyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

N¹-(6''-monomethoxytrityloxyhexyl)-2',3'-O-isopropylideneadenosine

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