{1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

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Chemical Name:{1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid
CAS No.:1420071-17-5
Molecular Formula:C₂₄H₂₄F₃N₃O₄
Molecular Weight:475.467
Hs Code.:

Synonyms:{1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

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Chemical Property of {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

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Technology Process of {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

There total 8 articles about {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1420070-67-2
tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

: 1420071-17-5
{1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 1420070-66-1
N-[2-(3-bromo-6-methoxy-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

: 1420071-17-5
{1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / diethyl ether / 2.5 h / 100 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C

2.2: pH 7 - 8

With hydrogenchloride; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; water;

Reference yield:

: 1219936-25-0
N-[2-bromo-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

: 1420071-17-5
{1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-6-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide / 1,4-dioxane / 21 h / 130 °C / Schlenk technique; Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide / ethyl acetate / 20 °C / Cooling with ice

3.1: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / diethyl ether / 2.5 h / 100 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C

4.2: pH 7 - 8

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; hydrogenchloride; potassium phosphate; N-Bromosuccinimide; copper(l) iodide; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; water; ethyl acetate;