Technology Process of 8-(6-(difluoromethoxy)pyridazin-3-yl)-5-(3,5-difluorophenoxy)-2,3,4,5-tetrahydro-1H-benzo[c]azepine
There total 9 articles about 8-(6-(difluoromethoxy)pyridazin-3-yl)-5-(3,5-difluorophenoxy)-2,3,4,5-tetrahydro-1H-benzo[c]azepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate; thiophenol;
In
ethanol; dichloromethane;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 1.5 h / 20 °C
2.1: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 2 h / 20 °C
2.2: 1.5 h / Heating / reflux
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
4.1: potassium acetate / dimethyl sulfoxide / 0.17 h
4.2: 3 h / 80 °C
5.1: caesium carbonate / water; N,N-dimethyl-formamide / 0.17 h
5.2: 2 h / 80 °C
6.1: potassium carbonate; thiophenol / ethanol; dichloromethane / 20 h / 20 °C
With
tributylphosphine; carbonochloridic acid 1-chloro-ethyl ester; potassium acetate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; potassium carbonate; caesium carbonate; thiophenol; N-ethyl-N,N-diisopropylamine; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
2.1: potassium acetate / dimethyl sulfoxide / 0.17 h
2.2: 3 h / 80 °C
3.1: caesium carbonate / water; N,N-dimethyl-formamide / 0.17 h
3.2: 2 h / 80 °C
4.1: potassium carbonate; thiophenol / ethanol; dichloromethane / 20 h / 20 °C
With
potassium acetate; potassium carbonate; caesium carbonate; thiophenol; N-ethyl-N,N-diisopropylamine;
In
ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
