(2S,5SR)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazine

Base Information

• Chemical Name: (2S,5SR)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazine
• CAS No.: 116907-51-8
• Molecular Formula: C₁₀H₁₈N₂O₂
• Molecular Weight: 198.265
• Hs Code.: 2933 99 80
• Mol file: 116907-51-8.mol

Synonyms:(2S,5SR)-(+)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYL-5- METHYLPYRAZINE FOR SYNTHESIS

Chemical Property of (2S,5SR)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazine

Chemical Property:

• Boiling Point: 103-104°C (21 hPa)
• PSA: 43.18000
• Density: 1.00 g/cm3 (20 °C)
• LogP: 0.37410
• Storage Temp.: Store below +30°C.

Purity/Quality:

98%Min ^*data from raw suppliers

(2S,5SR)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl- 5-methylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,5SR)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazine

There total 6 articles about (2S,5SR)-(+)-2,5-Dihydro-3,6-dimethoxy-2-isopropyl-5-methylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

trimethoxonium tetrafluoroborate (420-37-1) + cyclo(L-Val-D,L-Ala) (15136-26-2,15136-27-3,19943-22-7,22160-42-5,55904-05-7,55904-06-8,125410-17-5) → (3S,6S,R)-2,5-Dimethoxy-3-isopropyl-6-methyl-3,6-dihydropyrazine (81136-86-9,87936-33-2,116907-51-8,132153-49-2,132153-50-5)

Guidance literature:

In dichloromethane; for 72h;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (3S,6S,R)-2,5-Dimethoxy-3-isopropyl-6-methyl-3,6-dihydropyrazine (81136-86-9,87936-33-2,116907-51-8,132153-49-2,132153-50-5)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h

2: triethylamine / tetrahydrofuran; CHCl₃ / 1.) 3 h, - 70 degC, 2.) 30 min, room temp.

3: toluene / 12 h / Heating

4: 89 percent / CH₂Cl₂ / 72 h

With triethylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene;

Reference yield:

(S)-4-isopropyloxazolidine-2,5-dione (24601-74-9) → (3S,6S,R)-2,5-Dimethoxy-3-isopropyl-6-methyl-3,6-dihydropyrazine (81136-86-9,87936-33-2,116907-51-8,132153-49-2,132153-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; CHCl₃ / 1.) 3 h, - 70 degC, 2.) 30 min, room temp.

2: toluene / 12 h / Heating

3: 89 percent / CH₂Cl₂ / 72 h

With triethylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene;

upstream raw materials:

trimethoxonium tetrafluoroborate

cyclo(L-Val-D,L-Ala)

L-valine

L-Val-D,L-Ala-OCH₃

Downstream raw materials:

(2R,5S)-2-(3,4-Dimethoxy-benzyl)-5-isopropyl-3,6-dimethoxy-2-methyl-2,5-dihydro-pyrazine

(2S,5R)-2,5-dihydro-2-isopropyl-3,6-dimethoxy-5-benzyl-5-methylpyrazine

(2R,5S)-5-Isopropyl-3,6-dimethoxy-2-methyl-2-((E)-3-phenyl-allyl)-2,5-dihydro-pyrazine