4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

Base Information

Chemical Name:4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid
CAS No.:1093213-65-0
Molecular Formula:C₃₂H₃₃FN₄O₄
Molecular Weight:556.637
Hs Code.:

Synonyms:4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

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Chemical Property of 4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

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Technology Process of 4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

There total 5 articles about 4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093214-97-1
4-dimethylcarbamoylpiperidine-4-carboxylic acid ethyl ester

: 1093214-80-2
4-[5-(2-fluorobiphenyl-4-yl)-1,2,4-oxadiazole-3-yl]phenylmethanol

: 1093213-65-0
4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

Guidance literature:: 4-[5-(2-fluorobiphenyl-4-yl)-1,2,4-oxadiazole-3-yl]phenylmethanol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 - 50 ℃; for 0.25 - 0.5h;

4-dimethylcarbamoylpiperidine-4-carboxylic acid ethyl ester; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 75 - 85 ℃; for 0.5 - 1h;

Reference yield:

: 137045-30-8
2-fluoro-4-biphenylacetic acid

: 1093213-65-0
4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2 - 3 h / 130 - 140 °C

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.25 - 0.5 h / 0 - 50 °C

2.2: 0.5 - 1 h / 75 - 85 °C

With benzotriazol-1-ol; methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 41604-19-7
1-bromo-3-fluoro-4-phenylbenzene

: 1093213-65-0
4-dimethylcarbamoyl-1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / 1 h / 60 - 70 °C / Heating / reflux

1.2: 0.75 h / -20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2 - 3 h / 130 - 140 °C

3.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.25 - 0.5 h / 0 - 50 °C

3.2: 0.5 - 1 h / 75 - 85 °C

With iodine; benzotriazol-1-ol; magnesium; methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;