4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

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Chemical Name:4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine
CAS No.:142843-14-9
Molecular Formula:C₃₈H₆₀N₆O₉S₂
Molecular Weight:809.061
Hs Code.:

4-<2-<2-<<(2R,3S)-3-<<N<sup>α</sup>-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

Synonyms:4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

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Chemical Property of 4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

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Technology Process of 4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

There total 9 articles about 4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 135902-06-6
(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionic acid succinimido ester

: (S)-2-Amino-N-{(1S,2R)-1-cyclohexylmethyl-2-hydroxy-3-[(2-morpholin-4-yl-ethylcarbamoyl)-methanesulfonyl]-propyl}-3-(1H-imidazol-4-yl)-propionamide

: 142843-14-9
4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

Guidance literature:: With triethylamine; In dichloromethane; for 39h; Ambient temperature;
DOI:10.1021/jm00093a009

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 142843-14-9
4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / 48 h / Ambient temperature

2: trifluoroacetic acid / 1.5 h / Ambient temperature

3: 60 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 72 h / Ambient temperature

4: trifluoroacetic acid / 4 h / Ambient temperature

5: 42 percent / triethylamine / CH₂Cl₂ / 39 h / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00093a009

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 142843-14-9
4-<2-<2-<<(2R,3S)-3-<α-<(S)-2-<(tert-butylsulfonyl)methyl>-3-phenylpropionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxy-1-butyl>sulfonyl>acetamido>ethyl>morpholine

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / triethylamine / ethanol

2: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 92 percent / 48 h / Ambient temperature

4: trifluoroacetic acid / 1.5 h / Ambient temperature

5: 60 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), triethylamine / CH₂Cl₂ / 72 h / Ambient temperature

6: trifluoroacetic acid / 4 h / Ambient temperature

7: 42 percent / triethylamine / CH₂Cl₂ / 39 h / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm00093a009