Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester
CAS No.:911464-77-2
Molecular Formula:C₂₆H₃₃NO₄
Molecular Weight:423.552
Hs Code.:

Synonyms:Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

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Chemical Property of Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

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Technology Process of Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

There total 5 articles about Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 911465-39-9
[(E)-(R)-2,4-Bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

: 106-95-6
allyl bromide

: 911464-77-2
Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2006.07.029

Reference yield:

: 1,3-bis(3-methoxyphenyl)prop-2-en-1-ol

: 911464-77-2
Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; DMAP / tetrahydrofuran / 20 °C

2.1: 91 percent / aspartic acid-derived P-chirogenic diaminophosphine oxide; BSA; iPr2NEt / (η³-C3H5PdCl)2 / 3.5 h / 20 °C

3.1: SmI₂ / methanol; tetrahydrofuran / 4 h / 0 °C

3.2: 91 percent / NEt₃ / methanol / 1 h / 20 °C

4.1: 92 percent / NaH / dimethylformamide / 1 h / 20 °C

With pyridine; benzenesulfonamide; dmap; samarium diiodide; aspartic acid-derived P-chirogenic diaminophosphine oxide; sodium hydride; N-ethyl-N,N-diisopropylamine; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.07.029

Reference yield:

: 911464-96-5
Carbonic acid (E)-1,3-bis-(3-methoxy-phenyl)-allyl ester ethyl ester

: 911464-77-2
Allyl-[(E)-(R)-2,4-bis-(3-methoxy-phenyl)-but-3-enyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / aspartic acid-derived P-chirogenic diaminophosphine oxide; BSA; iPr2NEt / (η³-C3H5PdCl)2 / 3.5 h / 20 °C

2.1: SmI₂ / methanol; tetrahydrofuran / 4 h / 0 °C

2.2: 91 percent / NEt₃ / methanol / 1 h / 20 °C

3.1: 92 percent / NaH / dimethylformamide / 1 h / 20 °C

With benzenesulfonamide; samarium diiodide; aspartic acid-derived P-chirogenic diaminophosphine oxide; sodium hydride; N-ethyl-N,N-diisopropylamine; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.07.029