3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal

Base Information

Chemical Name:3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal
CAS No.:1024500-50-2
Molecular Formula:C₂₂H₁₄ClF₃N₄O₂
Molecular Weight:458.827
Hs Code.:

Synonyms:3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal

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Chemical Property of 3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal

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Technology Process of 3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal

There total 1 articles about 3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1024500-49-9
4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-2-{[2-(1,3-dioxolan-2-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one

: 1024500-50-2
3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal

Guidance literature:: 4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-2-{[2-(1,3-dioxolan-2-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one; With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃;

With water; sodium hydrogencarbonate; In 1,4-dioxane; ethyl acetate;

Reference yield: 63.0%

: 1018674-12-8
cyclopentyl L-leucinate hydrochloride

: 1024500-50-2
3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal

: 1024500-12-6
cyclopentyl N-(3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}propyl)-L-leucinate

Guidance literature:: cyclopentyl L-leucinate hydrochloride; 3-{[4-(2-chloro-4-fluorophenyl)-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]amino}propanal; With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 3h;

With water; In tetrahydrofuran;