11-(2-chlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

Base Information

Chemical Name:11-(2-chlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
CAS No.:82408-06-8
Molecular Formula:C₂₁H₂₁ClN₂O
Molecular Weight:352.864
Hs Code.:
Mol file:82408-06-8.mol

Synonyms:3,3-dimethyl-2,3,4,5,10,11-hexahydro-11-[(2-chloro)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 11-(2-chlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

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Technology Process of 11-(2-chlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

There total 3 articles about 11-(2-chlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 89-98-5
2-chloro-benzaldehyde

: 126-81-8
dimedone

: 95-54-5
1,2-diamino-benzene

: 82408-06-8
3,3-dimethyl-2,3,4,5,10,11-hexahydro-11-[(2-chloro)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one

Guidance literature:: With silica-supported nickel oxide nanocomposites; In ethanol; at 70 ℃; for 0.166667h; Microwave irradiation; Green chemistry;
DOI:10.1039/c6nj04013f

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 82408-06-8
3,3-dimethyl-2,3,4,5,10,11-hexahydro-11-[(2-chloro)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 1 h / 0 deg C bis RT

2: CH₂Cl₂ / Ambient temperature

With thionyl chloride; In dichloromethane;