(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

Base Information

Chemical Name:(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one
CAS No.:606972-24-1
Molecular Formula:C₁₉H₂₅NO₅
Molecular Weight:347.411
Hs Code.:

Synonyms:(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

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Chemical Property of (+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

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Technology Process of (+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

There total 7 articles about (+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 606972-21-8
(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-vinyloxyazetidin-2-one

: 606972-24-1
(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

Guidance literature:: With silica gel; pyridinium chlorochromate; In dichloromethane; for 6h; Heating;
DOI:10.1016/S0040-4020(03)00939-6

Reference yield:

: 10473-13-9
2,3-dimethyl-1-buten-3-ol

: 606972-24-1
(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 45 percent / NaH / dimethylformamide / 40 °C

2.1: 72 percent / SO₂Cl₂; LiClO₄; pyridine / CH₂Cl₂ / 0.17 h / -78 °C

3.1: 85 percent / K₂CO₃ / tetrahydrofuran; H₂O / 6 h / Heating

4.1: 91 percent / Ph₃P; Br₂; imidazole / CH₂Cl₂ / 0.17 h / 0 °C

5.1: tetrabutylammonium hydrogen sulfate; BuLi / tetrahydrofuran; cyclohexane / -78 - -30 °C

5.2: 70 percent / tetrahydrofuran; cyclohexane / -78 - 0 °C

6.1: 70 percent / PCC; silica gel / CH₂Cl₂ / 6 h / Heating

With pyridine; 1H-imidazole; n-butyllithium; sulfuryl dichloride; bromine; lithium perchlorate; tetra(n-butyl)ammonium hydrogensulfate; silica gel; sodium hydride; potassium carbonate; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00939-6

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 606972-24-1
(+/-)-1-[3'-(p-methoxybenzyloxy)-2'-methylene-3'-methylbutyl]-4-acetoxyazetidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 45 percent / NaH / dimethylformamide / 40 °C

2.1: 72 percent / SO₂Cl₂; LiClO₄; pyridine / CH₂Cl₂ / 0.17 h / -78 °C

3.1: 85 percent / K₂CO₃ / tetrahydrofuran; H₂O / 6 h / Heating

4.1: 91 percent / Ph₃P; Br₂; imidazole / CH₂Cl₂ / 0.17 h / 0 °C

5.1: tetrabutylammonium hydrogen sulfate; BuLi / tetrahydrofuran; cyclohexane / -78 - -30 °C

5.2: 70 percent / tetrahydrofuran; cyclohexane / -78 - 0 °C

6.1: 70 percent / PCC; silica gel / CH₂Cl₂ / 6 h / Heating

With pyridine; 1H-imidazole; n-butyllithium; sulfuryl dichloride; bromine; lithium perchlorate; tetra(n-butyl)ammonium hydrogensulfate; silica gel; sodium hydride; potassium carbonate; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00939-6