3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

Base Information

Chemical Name:3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate
CAS No.:1318792-65-2
Molecular Formula:C₇H₈O₃S*C₂₃H₂₈N₆O₂
Molecular Weight:592.719
Hs Code.:

Synonyms:3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

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Chemical Property of 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

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Technology Process of 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

There total 17 articles about 3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318792-63-0
AZD₇₉₂₉

: 104-15-4
toluene-4-sulfonic acid

: 1318792-65-2
3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

Guidance literature:: In isopropyl alcohol; at 17 - 25 ℃; for 120h; Inert atmosphere;

Reference yield:

: 1643-30-7
3-(4-bromophenyl)propionic acid

: 1318792-65-2
3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Reflux; Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 17 - 25 °C / Inert atmosphere

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

5.1: hydrogen fluoride / tetrahydrofuran / 3 h / 17 - 25 °C / Inert atmosphere

5.2: 17 - 25 °C / pH 10 - 11 / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 25 °C / Inert atmosphere

7.1: potassium carbonate / acetonitrile / 90 °C / Inert atmosphere

8.1: isopropyl alcohol / 120 h / 17 - 25 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; hydrogen fluoride; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 1318792-65-2
3-amino-6-(4-{3-[(3-methoxypropyl)amino]propyl}phenyl)-N-pyridin-3-ylpyrazine-2-carboxamide mono-tosylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 17 - 25 °C / Inert atmosphere

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 10 h / 90 °C / Inert atmosphere

4.1: hydrogen fluoride / tetrahydrofuran / 3 h / 17 - 25 °C / Inert atmosphere

4.2: 17 - 25 °C / pH 10 - 11 / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 25 °C / Inert atmosphere

6.1: potassium carbonate / acetonitrile / 90 °C / Inert atmosphere

7.1: isopropyl alcohol / 120 h / 17 - 25 °C / Inert atmosphere

With dmap; hydrogen fluoride; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; acetonitrile;