benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Base Information

Chemical Name:benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate
CAS No.:1415125-33-5
Molecular Formula:C₂₃H₂₀ClN₃O₄
Molecular Weight:437.882
Hs Code.:

Synonyms:benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Chemical Property of benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

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Technology Process of benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

There total 19 articles about benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415125-01-7
benzyl 4-amino-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1415125-34-6
benzyl 4-[(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 1415125-33-5
benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 1h;

Reference yield:

: 1415125-01-7
benzyl 4-amino-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1415125-02-8
N-(3-chloro-1H-pyrrolo [3,2-c]pyridin-4-yl)cyclopropane carboxamide

: 1415125-34-6
benzyl 4-[(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 1415125-33-5
benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 1h;

Reference yield:

: 1074-98-2
3-methyl-4-nitropyridine N-oxide

: 1415125-33-5
benzyl 4-[bis(cyclopropylcarbonyl)amino]-3-chloro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dimethyl amine / N,N-dimethyl-formamide / 15 h / 90 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

3.1: N-chloro-succinimide / dichloromethane / 5 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

6.1: chloroform / 0.25 h

6.2: 1 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

8.1: triethylamine / tetrahydrofuran / 1 h / -10 - 20 °C

With N-chloro-succinimide; hydrogen; dimethyl amine; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;