ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate

Base Information

• Chemical Name: ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate
• CAS No.: 126580-14-1
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.233
• Mol file: 126580-14-1.mol

Synonyms:ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate

Chemical Property of ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate

There total 5 articles about ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-hydroxy-1-ethoxycarbonyl-diazomethylcyclohexane (27262-60-8) → ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate (126580-14-1)

Guidance literature:

With pyridine; trichlorophosphate; at 0 ℃; for 6.5h;

DOI:10.1021/ja950971s

Reference yield: 45.0%

1-hydroxy-1-ethoxycarbonyl-diazomethylcyclohexane (27262-60-8) + tert-butyldimethyl((1-phenylprop-1-en-1-yl)oxy)silane (94287-27-1) → ethyl diazo(1-(1-oxo-1-phenylpropan-2-yl)cyclohexyl)acetate + ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate (126580-14-1)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; scandium tris(trifluoromethanesulfonate); In dichloromethane; at -20 ℃; Inert atmosphere;

DOI:10.1002/anie.202004557

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → ethyl 2-(cyclohex-1-en-1-yl)-2-diazoacetate (126580-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) ether, THF, -110 deg C, 2) -110 to -25 deg C

2: 80 percent / POCl₃, pyridine / 1) 0 deg C, 6 h, 2) r.t., 12 h

With pyridine; n-butyllithium; trichlorophosphate;

DOI:10.1021/jo00300a035

upstream raw materials:

1-hydroxy-1-ethoxycarbonyl-diazomethylcyclohexane

cyclohexanone

tert-butyldimethyl((1-phenylprop-1-en-1-yl)oxy)silane

Downstream raw materials:

ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate

ethyl 2-diazo-2-(2-oxocyclohexyl)acetate

(E)-ethyl 2-(2-(2,4,6-trimethoxyphenyl)cyclohexylidene)acetate