N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

Base Information

Chemical Name:N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine
CAS No.:1288960-94-0
Molecular Formula:C₂₇H₃₇N₃O₆
Molecular Weight:499.607
Hs Code.:

Synonyms:N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

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Chemical Property of N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

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Technology Process of N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

There total 10 articles about N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288961-33-0
C₂₃H₃₁N₃O₆

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1288960-94-0
N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: C₂₃H₃₁N₃O₆; Cyclopropanecarboxaldehyde; With 2-picoline borane complex; acetic acid; In methanol; at 10 - 35 ℃; for 3h;

With water; sodium hydrogencarbonate; In methanol;

Reference yield:

: 1288961-19-2
1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]propan-1-one

: 1288960-94-0
N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice

1.2: 0.5 h / 0 - 35 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: toluene-4-sulfonic acid / 4 h / 160 °C / 2250.23 Torr / Microwave irradiation

4.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice

5.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 1 h / 760.05 Torr

6.1: triethylamine / tetrahydrofuran / 4 h / 10 - 35 °C

7.1: sodium hydroxide / dimethyl sulfoxide / 2 h / 10 - 50 °C

8.1: trifluoroacetic acid / dichloromethane / 1 h / 10 - 35 °C

9.1: acetic acid; 2-picoline borane complex / methanol / 3 h / 10 - 35 °C

With hydrogenchloride; 2-picoline borane complex; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1288961-21-6
1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]propan-1-ol

: 1288960-94-0
N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N-(1,3-dioxan-5-ylmethyl)-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 15 h / 10 - 35 °C / Molecular sieve

2.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice

2.2: 0.5 h / 0 - 35 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: toluene-4-sulfonic acid / 4 h / 160 °C / 2250.23 Torr / Microwave irradiation

5.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice

6.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 1 h / 760.05 Torr

7.1: triethylamine / tetrahydrofuran / 4 h / 10 - 35 °C

8.1: sodium hydroxide / dimethyl sulfoxide / 2 h / 10 - 50 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 10 - 35 °C

10.1: acetic acid; 2-picoline borane complex / methanol / 3 h / 10 - 35 °C

With hydrogenchloride; tetrapropylammonium perruthennate; 2-picoline borane complex; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; sodium hydroxide; sodium nitrite; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;