Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

Base Information

Chemical Name:Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester
CAS No.:181271-46-5
Molecular Formula:C₂₄H₂₄N₂O₄S
Molecular Weight:436.532
Hs Code.:

Synonyms:Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

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Chemical Property of Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

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Technology Process of Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

There total 3 articles about Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 98-59-9
p-toluenesulfonyl chloride

: 181271-39-6
Acetic acid (6aR,9R)-1-(4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-yl)methyl ester

: 181271-46-5
Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.3987/com-96-7493

Reference yield:

: 85892-92-8
(5R)-6-methyl-(8R)-acetoxymethyl-Δ9,10-ergolene

: 181271-46-5
Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / CH₂Cl₂ / 5 h / Heating

2: 81 percent / Zn / aq. acetic acid / 5 h / 100 °C

3: 32 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With potassium carbonate; zinc; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7493

Reference yield:

: 181271-45-4
Acetic acid (6aR,9R)-7-cyano-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

: 181271-46-5
Acetic acid (6aR,9R)-7-(toluene-4-sulfonyl)-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Zn / aq. acetic acid / 5 h / 100 °C

2: 32 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With potassium carbonate; zinc; In acetic acid; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7493