N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Base Information

Chemical Name:N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide
CAS No.:1240516-64-6
Molecular Formula:C₂₁H₂₀ClN₃O₅S₂
Molecular Weight:493.992
Hs Code.:

Synonyms:N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

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Chemical Property of N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Chemical Property:

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Technology Process of N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

There total 8 articles about N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373162-26-5
C₂₅H₂₁Cl₂N₃O₇S₄

: 1240516-64-6
N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: With methanol; sodium hydroxide; at 60 ℃; for 2h;

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1240516-64-6
N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; triethylamine / dichloromethane

2: pyridine / dichloromethane

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: water; sodium carbonate / N,N-dimethyl-formamide / 85 °C

5: potassium carbonate / N,N-dimethyl-formamide

6: tetrabutyl ammonium fluoride / tetrahydrofuran

With pyridine; dmap; tetrabutyl ammonium fluoride; water; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.02.104

Reference yield:

: 1240518-05-1
1,1-dimethylethyl 3-amino-4-(methyloxy)-1H-indazole-1-carboxylate

: 1240516-64-6
N-[1-{[3,4-Bis(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: water; sodium carbonate / N,N-dimethyl-formamide / 85 °C

4: potassium carbonate / N,N-dimethyl-formamide

5: tetrabutyl ammonium fluoride / tetrahydrofuran

With pyridine; tetrabutyl ammonium fluoride; water; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.02.104