methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

Base Information

Chemical Name:methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate
CAS No.:1380805-70-8
Molecular Formula:C₃₅H₃₄Cl₂F₂N₂O₄
Molecular Weight:655.569
Hs Code.:

methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

Synonyms:methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

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Chemical Property of methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

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Technology Process of methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

There total 4 articles about methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380805-42-4
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-prop-2-ynyl-pyrrolidine-3-carbonitrile

: 148490-97-5
4-iodo-2-methoxybenzoic acid-methyl ester

: 1380805-70-8
methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In toluene; at 25 ℃; for 16h; Inert atmosphere; Darkness;

Reference yield:

: 1380805-27-5
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidine-3-carbonitrile

: 1380805-70-8
methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 14 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

3: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 25 °C / Inert atmosphere; Darkness

With copper(l) iodide; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 1380805-35-5
(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-1-(3-trimethylsilanyl-prop-2-ynyl)-pyrrolidine-3-carbonitrile

: 1380805-70-8
methyl 4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-methoxy-benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 25 °C / Inert atmosphere; Darkness

With copper(l) iodide; water; triethylamine; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; toluene;