2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

Base Information

Chemical Name:2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid
CAS No.:1601468-80-7
Molecular Formula:C₁₈H₁₂Cl₂FN₃O₂S
Molecular Weight:424.283
Hs Code.:

Synonyms:2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

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Chemical Property of 2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

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Technology Process of 2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

There total 4 articles about 2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 312303-66-5
4-(3,4-dichloro-phenyl)-thiazol-2-yl-hydrazine

: 111649-73-1
3-(4-fluorophenyl)-2-hydroxyacrylic acid

: 1601468-81-8
2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

: 1601468-80-7
2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: In ethanol; acetic acid; at 90 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.03.034

Reference yield:

: 586-08-3
4-(4-fluorophenyl)methylene-2-methyl-5(4H)-oxazolone

: 1601468-81-8
2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

: 1601468-80-7
2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 2 h / Reflux; Inert atmosphere

2: acetic acid; ethanol / 1 h / 90 °C

With hydrogenchloride; In ethanol; water; acetic acid;
DOI:10.1016/j.ejmech.2014.03.034

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1601468-81-8
2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

: 1601468-80-7
2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / acetic anhydride / 4 h / Inert atmosphere; Reflux

2: hydrogenchloride / water / 2 h / Reflux; Inert atmosphere

3: acetic acid; ethanol / 1 h / 90 °C

With hydrogenchloride; sodium acetate; In ethanol; water; acetic anhydride; acetic acid;
DOI:10.1016/j.ejmech.2014.03.034