2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester
CAS No.:208402-17-9
Molecular Formula:C₂₁H₂₃NO₃
Molecular Weight:337.419
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

There total 6 articles about 2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 100-46-9
benzylamine

: 208402-13-5
(Z)-3-[2-(2,2-Dimethyl-propionyloxy)-phenyl]-acrylic acid

: 208402-17-9
2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

Guidance literature:: With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1016/S0968-0896(98)00014-5

Reference yield:

: 14864-24-5
(Z)-2-(3-hydroxyprop-1-en-1-yl)phenol

: 208402-17-9
2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / DMAP / tetrahydrofuran / 14 h / 0 °C

2: 76 percent / DMAP, TEA / CH₂Cl₂ / 1 h / Ambient temperature

3: 100 percent / H₂O / tetrahydrofuran; acetic acid / 3 h / Ambient temperature

4: 94 percent / MnO₂ / CH₂Cl₂ / 5 h

5: 100 percent / NaClO₂, H₂O₂, Na₃PO₄ / H₂O; acetonitrile / 10 °C

6: 78 percent / DCC, HOBt, DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; manganese(IV) oxide; sodium chlorite; TEA; water; dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium phosphate; In tetrahydrofuran; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0968-0896(98)00014-5

Reference yield:

: 91-64-5
coumarin

: 208402-17-9
2,2-Dimethyl-propionic acid 2-((Z)-2-benzylcarbamoyl-vinyl)-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 44 percent / LAH / diethyl ether / 0.25 h / 0 °C

2: 83 percent / DMAP / tetrahydrofuran / 14 h / 0 °C

3: 76 percent / DMAP, TEA / CH₂Cl₂ / 1 h / Ambient temperature

4: 100 percent / H₂O / tetrahydrofuran; acetic acid / 3 h / Ambient temperature

5: 94 percent / MnO₂ / CH₂Cl₂ / 5 h

6: 100 percent / NaClO₂, H₂O₂, Na₃PO₄ / H₂O; acetonitrile / 10 °C

7: 78 percent / DCC, HOBt, DMAP / CH₂Cl₂ / 1 h / 0 °C

With dmap; manganese(IV) oxide; sodium chlorite; lithium aluminium tetrahydride; TEA; water; dihydrogen peroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium phosphate; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid; acetonitrile;
DOI:10.1016/S0968-0896(98)00014-5