C₃₇H₃₂FN₅O₈

Base Information

• Chemical Name: C₃₇H₃₂FN₅O₈
• CAS No.: 1403851-28-4
• Molecular Formula: C₃₇H₃₂FN₅O₈
• Molecular Weight: 693.688
• Mol file: 1403851-28-4.mol

Synonyms:C₃₇H₃₂FN₅O₈

Chemical Property of C₃₇H₃₂FN₅O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₃₂FN₅O₈

There total 5 articles about C₃₇H₃₂FN₅O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C37H34FN5O8 (1403851-27-3) → C37H32FN5O8 (1403851-28-4)

Guidance literature:

With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃;

Reference yield:

DL-5-fluorotryptophan (154-08-5,343-91-9,97749-24-1) → C37H32FN5O8 (1403851-28-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: chloro-trimethyl-silane / 20 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 1 h / 85 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

6.1: potassium carbonate; N,N,N,N-tetraethylammonium tetrafluoroborate / N,N-dimethyl-formamide; water / 72 h / Electrochemical reaction

7.1: water; lithium hydroxide / methanol / 18 h / 20 °C / Cooling with ice

7.2: 10 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

9.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / -20 - 20 °C

10.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

With chloro-trimethyl-silane; Bromotrichloromethane; water; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

5-fluoro-DL-tryptophan methyl ester hydrochloride → C37H32FN5O8 (1403851-28-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 1 h / 85 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: potassium carbonate; N,N,N,N-tetraethylammonium tetrafluoroborate / N,N-dimethyl-formamide; water / 72 h / Electrochemical reaction

6.1: water; lithium hydroxide / methanol / 18 h / 20 °C / Cooling with ice

6.2: 10 °C

7.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

8.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / -20 - 20 °C

9.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

With Bromotrichloromethane; water; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; potassium carbonate; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

DL-5-fluorotryptophan

C₂₅H₂₈FN₃O₅

C₂₅H₂₄FN₃O₅

C₃₇H₃₄FN₅O₈

Downstream raw materials:

C₃₆H₃₁FN₆O₇

Refernces