(S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Base Information

Chemical Name:(S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione
CAS No.:1614249-61-4
Molecular Formula:C₂₃H₂₃N₃O₃
Molecular Weight:389.454
Hs Code.:

Synonyms:(S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

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Chemical Property of (S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

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Technology Process of (S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

There total 7 articles about (S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1614249-59-0
1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-60-3
(R)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-61-4
(S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: With Chiralpak AS-H column; In methanol; carbon dioxide; Resolution of racemate; liquid CO₂;

Reference yield:

: 13509-52-9
1,3,6-trimethyluracil

: 1614249-60-3
(R)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-61-4
(S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc(II) chloride / chlorobenzene / 16 h / 110 °C / Inert atmosphere

2.1: bromine / chloroform / 2.5 h / 55 °C / Inert atmosphere

3.1: triethylamine / ethanol

3.2: 1.5 h / 20 °C

4.1: N-Methyldicyclohexylamine; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate / N,N-dimethyl acetamide / 15 h / 120 °C / Microwave irradiation; Inert atmosphere

5.1: ammonium formate; hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 50 °C

6.1: Chiralpak AS-H column / methanol; carbon dioxide / Resolution of racemate; liquid CO₂

With N-Methyldicyclohexylamine; palladium 10% on activated carbon; hydrogen; bromine; ammonium formate; palladium diacetate; triethylamine; zinc(II) chloride; tri tert-butylphosphoniumtetrafluoroborate; In methanol; ethanol; chloroform; N,N-dimethyl acetamide; carbon dioxide; chlorobenzene;

Reference yield:

: 444058-30-4
5-benzoyl-1,3,6-trimethylpyrimidine-2,4(1H,3H)-dione

: 1614249-60-3
(R)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

: 1614249-61-4
(S)-1,3-dimethyl-10-(5-methylfuran-2-yl)-5-phenyl-7,8,9,10-tetrahydropyrimido[4,5-a]indolizine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / chloroform / 2.5 h / 55 °C / Inert atmosphere

2.1: triethylamine / ethanol

2.2: 1.5 h / 20 °C

3.1: N-Methyldicyclohexylamine; tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate / N,N-dimethyl acetamide / 15 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: ammonium formate; hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 50 °C

5.1: Chiralpak AS-H column / methanol; carbon dioxide / Resolution of racemate; liquid CO₂

With N-Methyldicyclohexylamine; palladium 10% on activated carbon; hydrogen; bromine; ammonium formate; palladium diacetate; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In methanol; ethanol; chloroform; N,N-dimethyl acetamide; carbon dioxide;