N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

Base Information

Chemical Name:N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide
CAS No.:1365837-33-7
Molecular Formula:C₂₁H₂₅N₇O₂S
Molecular Weight:439.541
Hs Code.:

Synonyms:N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

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Chemical Property of N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

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Technology Process of N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

There total 7 articles about N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1365838-60-3
N₂-(trans-4-aminocyclohexyl)-6-[(methyloxy)methyl]-N₄-[1,3]thiazolo[5,4-b]pyridin-2-yl-2,4-pyrimidinediamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1365837-33-7
N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.166667h;

Reference yield:

: 1365838-40-9
N-[6-[(methyloxy)methyl]-2-(methylsulfonyl)-4-pyrimidinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: 1365837-33-7
N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 0.5 h / 150 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; isopropyl alcohol;

Reference yield:

: 1365838-39-6
N-[6-[(methyloxy)methyl]-2-(methylthio)-4-pyrimidinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: 1365837-33-7
N-(trans-4-{[4-[(methyloxy)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / N,N-dimethyl-formamide / 20 °C

2: isopropyl alcohol / 0.5 h / 150 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.17 h / 20 °C

With Oxone; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; isopropyl alcohol;