4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

Base Information

Chemical Name:4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide
CAS No.:1325224-46-1
Molecular Formula:C₂₇H₂₈F₅NO₃
Molecular Weight:509.516
Hs Code.:

Synonyms:4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

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Chemical Property of 4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

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Technology Process of 4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

There total 8 articles about 4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1325226-31-0
4-[(5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-5',5',13-trimethyl-17-(pentafluoroethyl)-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl]benzamide

: 1325224-46-1
4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

Guidance literature:: With sulfuric acid; In methanol; water; at 25 ℃; for 2.5h;
DOI:10.1002/cmdc.201800487

Reference yield:

: 1325226-16-1
(5R,8S,11R,13S,14S,17S)-11-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)phenyl]-5',5',13-trimethyl-17-(pentafluoroethyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17(4H)-diol

: 1325224-46-1
4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 23 °C

2: 4-methylmorpholine N-oxide; tetra-n-propylammonium perruthenate. / 3.5 h / 23 °C / Molecular sieve

3: sodium chlorite; sodium dihydrogen phosphate monohydrate / tetrahydrofuran; tert-butyl alcohol; water / 3.5 h / 0 °C

4: diethyl ether; tetrahydrofuran / 1.5 h / 23 °C

5: ammonia / methanol / 96 h / 85 °C / Sealed tube

6: sulfuric acid / methanol / 3 h / 23 °C

With sodium chlorite; tetra-n-propylammonium perruthenate.; sodium dihydrogen phosphate monohydrate; sulfuric acid; tetrabutyl ammonium fluoride; ammonia; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; water; tert-butyl alcohol;

Reference yield:

: 1262049-29-5
4-[(5R,8S,11R,13S,14S,17S)-5,17-dihydroxy-5',5',13-trimethyl-17-(pentafluoroethyl)-1,2,4,5,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxan]-11-yl]benzaldehyde

: 1325224-46-1
4-[(11β,17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium chlorite; sodium dihydrogen phosphate monohydrate / tetrahydrofuran; tert-butyl alcohol; water / 3.5 h / 0 °C

2: diethyl ether; tetrahydrofuran / 1.5 h / 23 °C

3: ammonia / methanol / 96 h / 85 °C / Sealed tube

4: sulfuric acid / methanol / 3 h / 23 °C

With sodium chlorite; sodium dihydrogen phosphate monohydrate; sulfuric acid; ammonia; In tetrahydrofuran; methanol; diethyl ether; water; tert-butyl alcohol;