Technology Process of 1-[(2E)-3-(3,5-difluorophenyl)-2-propenoyl]-4-piperidinecarbaldehyde
There total 3 articles about 1-[(2E)-3-(3,5-difluorophenyl)-2-propenoyl]-4-piperidinecarbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
{1-[(2E)-3-(3,5-difluorophenyl)-2-propenoyl]-4-piperidinyl}methanol;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.666667h;
With
triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C
2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.67 h / -78 °C
2.2: 2.5 h / -78 - 20 °C
With
oxalyl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C
2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 0.67 h / -78 °C
2.2: 2.5 h / -78 - 20 °C
With
oxalyl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
![{1-[(2E)-3-(3,5-difluorophenyl)-2-propenoyl]-4-piperidinyl}methanol](/Databaselist/images/loading.webp)
