(S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE

Base Information

Chemical Name:(S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE
CAS No.:116300-00-6
Molecular Formula:C12H21 N3 O3
Molecular Weight:255.31
Hs Code.:
Mol file:116300-00-6.mol

Synonyms:Carbamicacid, [1-(diazoacetyl)-3-methylbutyl]-, 1,1-dimethylethyl ester, (R)-

Suppliers and Price of (S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE 95.00%
5MG
$ 502.33

Total 3 raw suppliers

Chemical Property of (S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE

Chemical Property:

PSA：92.79000
LogP:2.26746

Purity/Quality:

98% ^*data from raw suppliers

(S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE

There total 1 articles about (S)-3-BOC-AMINO-1-DIAZO-5-METHYL-2-HEXANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: 116300-00-6
1-diazo-3(R)-<<(1,1-dimethylethoxy)carbonyl>amino>-5-methyl-2-hexanone

Guidance literature:: N-Boc-D-Leu; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.333333h;

diazomethane; In tetrahydrofuran; diethyl ether; at -20 ℃; for 0.5h; Further stages.;
DOI:10.1021/ol027116f

Reference yield:

: 116300-00-6
1-diazo-3(R)-<<(1,1-dimethylethoxy)carbonyl>amino>-5-methyl-2-hexanone

: (Z)-(2S,3S,6S,8R)-8-(9H-Fluoren-9-ylmethoxycarbonylamino)-3,6-dihydroxy-2,10-dimethyl-undec-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / PhCO₂Ag; Et₃N / 1.25 h

2: 80 percent / DIBAL-H / toluene / 1 h / -78 °C

3: 47 percent / tetrahydrofuran / 1.5 h / -70 - -40 °C

4: aq.HCl / dioxane / 1 h

5: DIPEA / CH₂Cl₂ / 0.25 h

6: pyridine / 3 h

7: Cl₂(PCy₃)(IMesH₂)Ru=CHPh / toluene / 3 h / 75 °C

8: HF; pyridine / tetrahydrofuran / 3 h / 20 °C

With pyridine; hydrogenchloride; hydrogen fluoride; silver benzoate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; 1: Wolff rearrangement;
DOI:10.1021/ol027116f

Reference yield:

: 116300-00-6
1-diazo-3(R)-<<(1,1-dimethylethoxy)carbonyl>amino>-5-methyl-2-hexanone

: (Z)-(2S,3R,6R,8R)-8-(9H-Fluoren-9-ylmethoxycarbonylamino)-3,6-dihydroxy-2,10-dimethyl-undec-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / PhCO₂Ag; Et₃N / 1.25 h

2: 80 percent / DIBAL-H / toluene / 1 h / -78 °C

3: 21 percent / tetrahydrofuran / 1.5 h / -70 - -40 °C

4: aq.HCl / dioxane / 1 h

5: DIPEA / CH₂Cl₂ / 0.25 h

6: pyridine / 3 h

7: Cl₂(PCy₃)(IMesH₂)Ru=CHPh / toluene / 3 h / 75 °C

8: HF; pyridine / tetrahydrofuran / 3 h / 20 °C

With pyridine; hydrogenchloride; hydrogen fluoride; silver benzoate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; 1: Wolff rearrangement;
DOI:10.1021/ol027116f