2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

Base Information

Chemical Name:2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate
CAS No.:1374561-21-3
Molecular Formula:C₁₈H₁₆F₃NO₃
Molecular Weight:351.325
Hs Code.:

Synonyms:2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

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Technology Process of 2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

There total 4 articles about 2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1374561-35-9
2-[2,2-difluoro-2-(phenylsulfonyl)ethylamino]-1-(3-fluoro-2-methylphenyl)2-oxoethyl benzoate

: 1374561-21-3
2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

Guidance literature:: With sodium acetate; magnesium; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/ejoc.201101518

Reference yield:

: 1374561-02-0
2-[2,2-difluoro-2-(phenylthio)ethylamino]-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

: 1374561-21-3
2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide / 20 °C

With sodium acetate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201101518

Reference yield:

: 147624-13-3
3-fluoro-2-methylbenzaldehyde

: 1374561-21-3
2-(2,2-difluoroethylamino)-1-(3-fluoro-2-methylphenyl)-2-oxoethyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 20 °C / Neat (no solvent)

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide / 20 °C

With sodium acetate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Passerini reaction;
DOI:10.1002/ejoc.201101518