2-Methoxy-5-phenoxyaniline

Base Information

• Chemical Name: 2-Methoxy-5-phenoxyaniline
• CAS No.: 116289-67-9
• Molecular Formula: C13H13 N O2
• Molecular Weight: 215.25
• Hs Code.: 2922299090
• European Community (EC) Number: 673-735-3
• DSSTox Substance ID: DTXSID40921987
• Mol file: 116289-67-9.mol

Synonyms:2-methoxy-5-phenoxyaniline;5-Phenoxy-O-Anisidine;116289-67-9;SCHEMBL3045451;DTXSID40921987;SCDKUQBOSDILAR-UHFFFAOYSA-N;MFCD00270120;AKOS022520788;SB79238;AS-82301;FT-0682115;E85620;A803590

Chemical Property of 2-Methoxy-5-phenoxyaniline

Chemical Property:

• Vapor Pressure: 6.84E-05mmHg at 25°C
• Melting Point: 68-70°C
• Refractive Index: 1.598
• Boiling Point: 343.9°C at 760 mmHg
• PKA: 3.81±0.10(Predicted)
• Flash Point: 177.4°C
• PSA: 44.48000
• Density: 1.155g/cm³
• LogP: 3.65090
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 215.094628657
• Heavy Atom Count: 16
• Complexity: 204

Purity/Quality:

98%Min ^*data from raw suppliers

5-Phenoxy-O-anisidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)OC2=CC=CC=C2)N

Technology Process of 2-Methoxy-5-phenoxyaniline

There total 1 articles about 2-Methoxy-5-phenoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-2-nitro-4-phenoxy-benzene (791108-77-5) → 2-methoxy-5-phenoxy-aniline (116289-67-9)

Guidance literature:

With platinum; Hydrogenation;

DOI:10.1021/ja01265a038

Reference yield: 54.0%

4-chloro-2-(3-pyridyl)-6-(trifluoromethyl)pyrimidine (204394-69-4) + 2-methoxy-5-phenoxy-aniline (116289-67-9) → 4-(2-Methoxy-5-phenoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine (438248-20-5)

Guidance literature:

Reference yield: 50.0%

Hexafluoroacetone (684-16-2) + 2-methoxy-5-phenoxy-aniline (116289-67-9) → 2-(4-amino-5-methoxy-2-phenoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Guidance literature:

at 60 ℃; for 96h;

DOI:10.1002/ejoc.200300501

upstream raw materials:

1-methoxy-2-nitro-4-phenoxy-benzene

Downstream raw materials:

2-bromo-1-methoxy-4-phenoxy-benzene

2-iodo-1-methoxy-4-phenoxy-benzene

4-(2-Methoxy-5-phenoxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine