(5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

Base Information

Chemical Name:(5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol
CAS No.:1207630-66-7
Molecular Formula:C₂₈H₃₆FNO₂
Molecular Weight:437.598
Hs Code.:

Synonyms:(5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

Suppliers and Price of (5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

Chemical Property:

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Technology Process of (5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

There total 7 articles about (5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1207630-65-6
(5'R)-3β-acetoxy-17β-[2-(4-fluorophenyl)-phenyl-4,5-dihydrooxazol-5-yl]androst-5-ene

: 1207630-66-7
(5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 8h;
DOI:10.1016/j.steroids.2009.08.001

Reference yield:

: 1778-02-5
Pregnenolone acetate

: 1207630-66-7
(5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

Guidance literature:: Multi-step reaction with 7 steps

1: boron trifluoride diethyl etherate / methanol

2: potassium borohydride / methanol / 20 °C

3: aluminum oxide / Alkaline conditions; Microwave irradiation

4: triphenylphosphine; tetrachloromethane / Reflux

5: sodium azide / N,N-dimethyl-formamide / 90 °C

6: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

7: sodium methylate / methanol / 20 °C

With tetrachloromethane; aluminum oxide; sodium azide; potassium borohydride; boron trifluoride diethyl etherate; sodium methylate; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; 4: |Appel Halogenation;
DOI:10.1016/j.steroids.2014.05.009

Reference yield:

: 1693-63-6
3β,21-diacetoxypregn-5-en-20-one

: 1207630-66-7
(5'R)-17β-[2-(4-fluorophenyl)-4,5-dihydrooxazol-5-yl]androst-5-en-3β-ol

Guidance literature:: Multi-step reaction with 6 steps

1: potassium borohydride / methanol / 20 °C

2: aluminum oxide / Alkaline conditions; Microwave irradiation

3: triphenylphosphine; tetrachloromethane / Reflux

4: sodium azide / N,N-dimethyl-formamide / 90 °C

5: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

6: sodium methylate / methanol / 20 °C

With tetrachloromethane; aluminum oxide; sodium azide; potassium borohydride; boron trifluoride diethyl etherate; sodium methylate; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; 3: |Appel Halogenation;
DOI:10.1016/j.steroids.2014.05.009