Cryptophycin 46

Base Information

Chemical Name:Cryptophycin 46
CAS No.:162679-35-8
Molecular Formula:C35H43 Cl N2 O7
Molecular Weight:639.189
Hs Code.:
DSSTox Substance ID:DTXSID001046154
Nikkaji Number:J833.398J
Wikidata:Q77382361
Metabolomics Workbench ID:112255
ChEMBL ID:CHEMBL492459

Synonyms:cryptophycin 46;cryptophycin-46

Suppliers and Price of Cryptophycin 46

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Cryptophycin 46

Chemical Property:

XLogP3:7.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:638.2758794
Heavy Atom Count:45
Complexity:1040

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Cryptophycin
Canonical SMILES:CC1CNC(=O)C(NC(=O)C=CCC(OC(=O)C(OC1=O)CC(C)C)C(C)C=CC2=CC=CC=C2)CC3=CC(=C(C=C3)OC)Cl
Isomeric SMILES:C[C@@H]1CNC(=O)[C@@H](NC(=O)/C=C/C[C@H](OC(=O)[C@@H](OC1=O)CC(C)C)[C@H](C)/C=C/C2=CC=CC=C2)CC3=CC(=C(C=C3)OC)Cl

Technology Process of Cryptophycin 46

There total 1 articles about Cryptophycin 46 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: (S)-2-((R)-3-Amino-2-methyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(S)-1-carboxy-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

: 162679-35-8
(E)-(3S,6R,10S,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 2.5h;
DOI:10.1021/ja00114a011

Reference yield:

: 162679-35-8
(E)-(3S,6R,10S,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

: 155379-98-9
cryptophycin-12

Guidance literature:: Multi-step reaction with 2 steps

1: 0.1 mg / m-chloroperbenzoic acid / CH₂Cl₂ / 96 h / Ambient temperature

2: aq. NaOH / acetone / 5 h / Ambient temperature

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone;
DOI:10.1021/ja00090a020

Reference yield:

: 162679-35-8
(E)-(3S,6R,10S,16S)-10-(3-Chloro-4-methoxy-benzyl)-3-isobutyl-6-methyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

: cryptophycin F methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.1 mg / m-chloroperbenzoic acid / CH₂Cl₂ / 96 h / Ambient temperature

2: aq. NaOH / acetone / 5 h / Ambient temperature

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetone;
DOI:10.1021/ja00090a020