4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

Base Information

Chemical Name:4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester
CAS No.:1291090-33-9
Molecular Formula:C₂₇H₃₀N₂O₄
Molecular Weight:446.546
Hs Code.:

Synonyms:4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

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Chemical Property of 4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

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Technology Process of 4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

There total 1 articles about 4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 7425-53-8
ethyl 4-iodobutyrate

: 1125471-66-0
8-[4-(dimethylamino)phenyl]-1,2-dimethylpyrano[3,2-e]indol-7(3H)-one

: 1291090-33-9
4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

Guidance literature:: 8-[4-(dimethylamino)phenyl]-1,2-dimethylpyrano[3,2-e]indol-7(3H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

ethyl 4-iodobutyrate; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;
DOI:10.1016/j.tet.2011.01.075

Reference yield: 92.0%

: 1291090-33-9
4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

: 1291090-37-3
4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid

Guidance literature:: 4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester; With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=7;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 1291090-33-9
4-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyric acid ethyl ester

: 1291090-24-8
N-[4-(2-amino-9H-purin-6-yloxymethyl)-benzyl]-2-[8-(4-dimethylamino-phenyl)-1,2-dimethyl-7-oxo-7H-pyrano[3,2-e]indol-3-yl]-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 0 °C

1.2: pH 7

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.01.075