methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

Base Information

Chemical Name:methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate
CAS No.:1442444-16-7
Molecular Formula:C₂₀H₁₈INO₅
Molecular Weight:479.271
Hs Code.:

Synonyms:methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

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Chemical Property of methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

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Technology Process of methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

There total 4 articles about methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1442444-15-6
methyl [2-chloromethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

: 1442444-16-7
methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

Guidance literature:: With water; silver nitrate; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/chem.201300064

Reference yield:

: 1442444-12-3
methyl [1-(2-iodobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate

: 1442444-16-7
methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dibenzoyl peroxide; N-chloro-succinimide / tetrachloromethane / 2.5 h / Inert atmosphere; Reflux

2: silver nitrate; water / tetrahydrofuran / 1 h / 20 °C

With N-chloro-succinimide; water; silver nitrate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1002/chem.201300064

Reference yield:

: 7588-36-5
methyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate

: 1442444-16-7
methyl [2-hydroxymethyl-1-(2-iodobenzoyl)-5-methoxy-1H-indol-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.08 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: dibenzoyl peroxide; N-chloro-succinimide / tetrachloromethane / 2.5 h / Inert atmosphere; Reflux

3.1: silver nitrate; water / tetrahydrofuran / 1 h / 20 °C

With N-chloro-succinimide; water; potassium hexamethylsilazane; silver nitrate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; toluene;
DOI:10.1002/chem.201300064