4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

Base Information

Chemical Name:4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one
CAS No.:1359815-42-1
Molecular Formula:C₂₈H₂₆Cl₂N₂O₃
Molecular Weight:509.432
Hs Code.:

Synonyms:4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

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Chemical Property of 4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

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Technology Process of 4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

There total 8 articles about 4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1359815-40-9
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chlorobenzoyl)pyridine-2(1H)-one

: 1359815-42-1
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

Guidance literature:: With sodium tetrahydroborate; ethanol; for 1h; Cooling with ice;

Reference yield:

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 1359815-42-1
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: orthoformic acid triethyl ester; acetic anhydride / 15 h / Reflux

1.2: 2.33 h / 20 - 90 °C

2.1: trichlorophosphate / 1 h / 90 °C

3.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / Reflux

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 15 h / 50 °C

5.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Cooling with ice

7.1: sodium tetrahydroborate; ethanol / 1 h / Cooling with ice

With sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; water; palladium diacetate; acetic anhydride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; orthoformic acid triethyl ester; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1359818-45-3
4-chloro-1-benzyl-5-(ethoxycarbonyl-)pyridine-2(1H)-one

: 1359815-42-1
4-(3-chloro-4-isopropoxyphenylamino)-1-benzyl-5-(4-chloro-α-hydroxybenzyl)pyridine-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / Reflux

2: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 15 h / 50 °C

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

4: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C / Cooling with ice

5: sodium tetrahydroborate; ethanol / 1 h / Cooling with ice

With sodium tetrahydroborate; lithium hydroxide monohydrate; ethanol; water; palladium diacetate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;