(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

Base Information

Chemical Name:(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid
CAS No.:1207438-55-8
Molecular Formula:C₁₈H₂₄ClNO₄
Molecular Weight:353.846
Hs Code.:

Synonyms:(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

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Chemical Property of (2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

Chemical Property:

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Technology Process of (2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

There total 5 articles about (2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1207438-57-0
C₁₃H₁₆ClNO₂*BrH

: 1207438-55-8
(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

Guidance literature:: C₁₃H₁₆ClNO₂*BrH; With sodium hydroxide; In water;

di-tert-butyl dicarbonate; With water; In 1,2-dimethoxyethane; at 20 ℃; for 20h;

With citric acid; In water; pH=Ca. 3;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-38-7
tert-butyl 4-[(3-chlorophenyl)(cyano)methylidene]piperidine-1-carboxylate

: 1207438-55-8
(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

2.1: hydrogen bromide; water / 5 h / Reflux

3.1: sodium hydroxide / water

3.2: 20 h / 20 °C

3.3: pH Ca_. 3

With sodium tetrahydroborate; water; hydrogen bromide; sodium hydroxide; In methanol; water;
DOI:10.1016/j.bmc.2013.05.025

Reference yield:

: 1207438-45-6
tert-butyl 4-[(RS)-(3-chlorophenyl)(cyano)methyl]piperidine-1-carboxylate

: 1207438-55-8
(2RS)-2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-(3-chlorophenyl)ethanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; water / 5 h / Reflux

2.1: sodium hydroxide / water

2.2: 20 h / 20 °C

2.3: pH Ca_. 3

With water; hydrogen bromide; sodium hydroxide; In water;
DOI:10.1016/j.bmc.2013.05.025