6-Ethoxypyridin-3-ol

Base Information

• Chemical Name: 6-Ethoxypyridin-3-ol
• CAS No.: 116178-39-3
• Molecular Formula: C7H9 N O2
• Molecular Weight: 139.154
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID20555340
• Wikidata: Q82436659
• Mol file: 116178-39-3.mol

Synonyms:6-ethoxypyridin-3-ol;116178-39-3;3-Pyridinol,6-ethoxy-(9CI);3-Pyridinol, 6-ethoxy-;SCHEMBL15633679;DTXSID20555340;BBEYKPDYKSDPNA-UHFFFAOYSA-N;MFCD18819177;SB53236;BS-19266;CS-0090994;D75011

Chemical Property of 6-Ethoxypyridin-3-ol

Chemical Property:

• PSA: 42.35000
• LogP: 1.18590
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98%min ^*data from raw suppliers

6-Ethoxypyridin-3-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC=C(C=C1)O

Technology Process of 6-Ethoxypyridin-3-ol

There total 15 articles about 6-Ethoxypyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-ethoxy-1,4-oxazepine (116178-33-7) → 2-ethoxy-5-hydroxypyridine (116178-39-3)

Guidance literature:

In toluene; at 45 ℃; for 1h;

DOI:10.1248/cpb.38.2911

Reference yield:

3-Oxo-2-azabicyclo<2.2.0>hex-5-ene (4432-69-3) → 2-ethoxy-5-hydroxypyridine (116178-39-3)

Guidance literature:

Multi-step reaction with 6 steps

1: dimethylformamide

2: m-chloroperbenzoic acid (m0CPBA)

3: 100 percent / Al₂O₃ / diethyl ether; methanol

4: various solvent(s) / 1.5 h / 140 °C

5: CH₂Cl₂

6: 60 percent / benzene / 1 h / 45 °C

With aluminum oxide; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;

Reference yield:

2-(tert-butyldimethylsilyl)-2-azabicyclo<2.2.0>hex-5-en-3-one (116178-12-2) → 2-ethoxy-5-hydroxypyridine (116178-39-3)

Guidance literature:

Multi-step reaction with 5 steps

1: m-chloroperbenzoic acid (m0CPBA)

2: 100 percent / Al₂O₃ / diethyl ether; methanol

3: various solvent(s) / 1.5 h / 140 °C

4: CH₂Cl₂

5: 60 percent / benzene / 1 h / 45 °C

With aluminum oxide; 3-chloro-benzenecarboperoxoic acid; In methanol; diethyl ether; dichloromethane; benzene;

upstream raw materials:

5-ethoxy-1,4-oxazepine

3-Oxo-2-azabicyclo<2.2.0>hex-5-ene

1,4-oxazepin-5-one

2-(tert-butyldimethylsilyl)-2-azabicyclo<2.2.0>hex-5-en-3-one

Downstream raw materials:

2,5-dihydroxypyridine