12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

Base Information

Chemical Name:12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine
CAS No.:1450805-09-0
Molecular Formula:C₂₂H₂₂ClN₃
Molecular Weight:363.89
Hs Code.:

Synonyms:12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

Suppliers and Price of 12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

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Technology Process of 12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

There total 3 articles about 12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 164026-59-9
2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

: 1450805-09-0
12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

Guidance literature:: With PPA; In toluene; for 4h; Reagent/catalyst; Solvent; Temperature; Reflux;
DOI:10.1002/cjoc.201201247

Reference yield: 75.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 164026-59-9
2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

: 1334110-44-9
5'-(4-chlorophenyl)-6',7',8',9'-tetrahydro-1'H-spiro[cyclohexane-1,2'-pyrimido[4,5-b]quinolin]-4'(3'H)-one

: 1450805-09-0
12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

Guidance literature:: With zinc(II) chloride; at 140 ℃;
DOI:10.1002/cjoc.201201247

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1450805-09-0
12-(4-chlorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1,8]naphthyridin-11-amine

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / ethanol / 1 h / 80 °C

2: ammonium acetate / benzene / 10 h / 100 °C

3: zinc(II) chloride / 4 h / 140 °C

With piperidine; ammonium acetate; zinc(II) chloride; In ethanol; benzene;
DOI:10.1007/s11030-018-9897-1